IUBMB Enzyme Nomenclature


Accepted name: dTDP-6-deoxy-L-talose 4-dehydrogenase (NADP+)

Reaction: dTDP-6-deoxy-β-L-talose + NADP+ = dTDP-4-dehydro-β-L-rhamnose + NADPH + H+

Glossary: dTDP-4-dehydro-β-L-rhamnose = dTDP-4-dehydro-6-deoxy-β-L-mannose
dTDP-6-deoxy-β-L-talose = dTDP-β-L-pneumose

Other name(s): thymidine diphospho-6-deoxy-L-talose dehydrogenase; TDP-6-deoxy-L-talose dehydrogenase; thymidine diphospho-6-deoxy-L-talose dehydrogenase; dTDP-6-deoxy-L-talose dehydrogenase (4-reductase); dTDP-6-deoxy-L-talose 4-dehydrogenase; dTDP-6-deoxy-L-talose:NADP+ 4-oxidoreductase

Systematic name: dTDP-6-deoxy-β-L-talose:NADP+ 4-oxidoreductase

Comments: Oxidation on the 4-position of the hexose moiety takes place only while the substrate is bound to another enzyme that catalyses epimerization at C-3 and C-5.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37250-65-0


1. Gaugler, R.W. and Gabriel, O. Biological mechanisms involved in the formation of deoxy sugars. VII. Biosynthesis of 6-deoxy-L-talose. J. Biol. Chem. 248 (1973) 6041-6049. [PMID: 4199258]

[EC created 1972]

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