IUBMB Enzyme Nomenclature


Accepted name: 21-hydroxysteroid dehydrogenase (NADP+)

Reaction: pregnan-21-ol + NADP+ = pregnan-21-al + NADPH + H+

Other name(s): 21-hydroxy steroid dehydrogenase; 21-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase; 21-hydroxy steroid dehydrogenase (nicotinamide adenine dinucleotide phosphate); NADP-21-hydroxysteroid dehydrogenase; 21-hydroxysteroid dehydrogenase (NADP)

Systematic name: 21-hydroxysteroid:NADP+ 21-oxidoreductase

Comments: Acts on a number of 21-hydroxycorticosteroids.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37250-76-3


1. Monder, C. and White, A. The 21-hydroxysteroid dehydrogenases of liver. A nicotinamide adenine dinucleotide phosphate dehydrogenase and two nicotinamide adenine dinucleotide dehydrogenases. J. Biol. Chem. 240 (1965) 71-77.

[EC created 1972]

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