IUBMB Enzyme Nomenclature

EC 1.1.1.16

Accepted name: galactitol 2-dehydrogenase

Reaction: galactitol + NAD+ = D-tagatose + NADH + H+

For diagram of reaction click here.

Other name(s): dulcitol dehydrogenase; AtuSorbD (gene name); galactitol:NAD+ 2-oxidoreductase

Systematic name: galactitol:NAD+ 2-oxidoreductase (D-tagatose-forming)

Comments: Also converts other alditols containing an L-threo-configuration adjacent to a primary alcohol group into the corresponding sugars.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9028-23-3

References:

1. Shaw, D.R.D. Polyol dehydrogenases 3. Galactitol dehydrogenase and D-iditol dehydrogenase. Biochem. J. 64 (1956) 394-405. [PMID: 13373783]

2. Wichelecki, D.J., Vetting, M.W., Chou, L., Al-Obaidi, N., Bouvier, J.T., Almo, S.C. and Gerlt, J.A. ATP-binding cassette (ABC) transport system solute-binding protein-guided identification of novel D-altritol and galactitol catabolic pathways in Agrobacterium tumefaciens C58. J. Biol. Chem. 290 (2015) 28963–28976. [PMID: 26472925]

[EC 1.1.1.16 created 1961]


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