IUBMB Enzyme Nomenclature


Accepted name: 2-dehydropantolactone reductase (Re-specific)

Reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+

Other name(s): 2-oxopantoyl lactone reductase; ketopantoyl lactone reductase; 2-ketopantoyl lactone reductase; 2-dehydropantoyl-lactone reductase (A-specific); (R)-pantolactone:NADP+ oxidoreductase (A-specific); 2-dehydropantolactone reductase (A-specific)

Systematic name: (R)-pantolactone:NADP+ oxidoreductase (Re-specific)

Comments: The yeast enzyme differs from that from Escherichia coli [EC 2-dehydropantolactone reductase (Si-specific)], which is specific for the Si-face of NADP+, and in receptor requirements from EC 3-hydroxycyclohexanone dehydrogenase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37211-75-9


1. King, H.L., Jr., Dyar, R.E. and Wilken, D.R. Ketopantoyl lactone and ketopantoic acid reductases. Characterization of the reactions and purification of two forms of ketopantoyl lactone reductase. J. Biol. Chem. 247 (1972) 4689-4695. [PMID: 4603075]

2. Wilken, D.R., King, H.L., Jr. and Dyar, R.E. Ketopantoic acid and ketopantoyl lactone reductases. Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate. J. Biol. Chem. 250 (1975) 2311-2314. [PMID: 234966]

[EC created 1976, modified 1986, modified 1999, modified 2013]

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