IUBMB Enzyme Nomenclature


Accepted name: cholest-5-ene-3β,7α-diol 3β-dehydrogenase

Reaction: cholest-5-ene-3β,7α-diol + NAD+ = 7α-hydroxycholest-4-en-3-one + NADH + H+

For diagram click here.

Other name(s): 3β-hydroxy-δ5-C27-steroid oxidoreductase (ambiguous)

Systematic name: Cholest-5-ene-3β,7α-diol:NAD+ 3-oxidoreductase

Comments: Highly specific for 3β-hydroxy-C27-steroids with δ5-double bond.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 56626-16-5


1. Wikvall, K. Purification and properties of a 3β-hydroxy-δ5-C27-steroid oxidoreductase from rabbit liver microsomes. J. Biol. Chem. 256 (1981) 3376-3380. [PMID: 6937465]

2. Schwarz, M., Wright, A.C., Davis, D.L., Nazer, H., Bjorkhem, I. and Russell, D.W. The bile acid synthetic gene 3β-hydroxy-Δ5-C27-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis. J. Clin. Invest. 106 (2000) 1175-1184. [PMID: 11067870]

[EC created 1983]

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