IUBMB Enzyme Nomenclature


Accepted name: aldose reductase

Reaction: alditol + NAD(P)+ = aldose + NAD(P)H + H+

For diagram of reaction click here.

Other name(s): polyol dehydrogenase (NADP+); ALR2; alditol:NADP+ oxidoreductase; alditol:NADP+ 1-oxidoreductase; NADPH-aldopentose reductase; NADPH-aldose reductase; aldehyde reductase (misleading)

Systematic name: alditol:NAD(P)+ 1-oxidoreductase

Comments: Has wide specificity.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9028-31-3


1. Attwood, M.A. and Doughty, C.C. Purification and properties of calf liver aldose reductase. Biochim. Biophys. Acta 370 (1974) 358-368. [PMID: 4216364]

2. Boghosian, R.A. and McGuinness, E.T. Affinity purification and properties of porcine brain aldose reductase. Biochim. Biophys. Acta 567 (1979) 278-286. [PMID: 36151]

3. Hers, H.G. L’Aldose-réductase. Biochim. Biophys. Acta 37 (1960) 120-126. [PMID: 14401390]

4. Scher, B.M. and Horecker, B.L. Pentose metabolism in Candida. 3. The triphosphopyridine nucleotide-specific polyol dehydrogenase of Candida utilis. Arch. Biochem. Biophys. 116 (1966) 117-128. [PMID: 4381350]

[EC created 1961 (EC created 1972, incorporated 1978), modified 2019]

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