IUBMB Enzyme Nomenclature


Accepted name: 3β(or 20α)-hydroxysteroid dehydrogenase

Reaction: 5α-androstan-3β,17β-diol + NADP+ = 17β-hydroxy-5α-androstan-3-one + NADPH + H+

Other name(s): progesterone reductase; dehydrogenase, 3β,20α-hydroxy steroid; 3β,20α-hydroxysteroid oxidoreductase

Systematic name: 3β(or 20α)-hydroxysteroid:NADP+ oxidoreductase

Comments: Also acts on 20α-hydroxysteroids.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 82869-26-9


1. Sharaf, M.A. and Sweet, F. Dual activity at an enzyme active site: 3β,20α-hydroxysteroid oxidoreductase from fetal blood. Biochemistry 21 (1982) 4615-4620. [PMID: 6958329]

[EC created 1986]

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