Reaction: 6-lactoyl-5,6,7,8-tetrahydropterin + NADP+ = 6-pyruvoyltetrahydropterin + NADPH + H+
For diagram of reaction click here.
Other name(s): 6-pyruvoyltetrahydropterin reductase; 6PPH4(2'-oxo) reductase; 6-pyruvoyl tetrahydropterin (2'-oxo)reductase; 6-pyruvoyl-tetrahydropterin 2'-reductase; pyruvoyl-tetrahydropterin reductase
Systematic name: 6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase
Comments: Not identical with EC 1.1.1.153 sepiapterin reductase.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 97089-79-7
References:
1. Milstien, S. and Kaufman, S. Biosynthesis of tetrahydrobiopterin: conversion of dihydroneopterin triphosphate to tetrahydropterin intermediates. Biochem. Biophys. Res. Commun. 128 (1985) 1099-1107. [PMID: 4004850]