IUBMB Enzyme Nomenclature


Accepted name: histidinol dehydrogenase

Reaction: L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 3 H+

For diagram click here.

Other name(s): L-histidinol dehydrogenase

Systematic name: L-histidinol:NAD+ oxidoreductase

Comments: Also oxidizes L-histidinal. The Neurospora enzyme also catalyses the reactions of EC (phosphoribosyl-AMP cyclohydrolase) and EC (phosphoribosyl-ATP diphosphatase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9028-27-7


1. Adams, E. Enzymatic synthesis of histidine from histidinol. J. Biol. Chem. 209 (1954) 829-846.

2. Adams, E. L-Histidinal, a biosynthetic precursor of histidine. J. Biol. Chem. 217 (1955) 325-344.

3. Loper, J.C. Histidinol dehydrogenase from Salmonella typhimurium. Crystallization and composition studies. J. Biol. Chem. 243 (1968) 3264-3272. [PMID: 4872177]

4. Yourno, J. and Ino, I. Purification and crystallization of histidinol dehydrogenase from Salmonella typhimurium LT-2. J. Biol. Chem. 243 (1968) 3273-3276. [PMID: 4872176]

[EC created 1961]

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