Reaction: (5Z,13E)-(15S)-6,9α-epoxy-11α,15-dihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-6,9α-epoxy-11α-hydroxy-15-oxoprosta-5,13-dienoate + NADPH + H+
Other name(s): prostacyclin dehydrogenase; PG I2 dehydrogenase; prostacyclin dehydrogenase; NADP-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase; NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase; 15-hydroxyprostaglandin-I dehydrogenase (NADP)
Systematic name: (5Z,13E)-(15S)-6,9α-epoxy-11α,15-dihydroxyprosta-5,13-dienoate:NADP+ 15-oxidoreductase
Comments: Specific for prostaglandin I2.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 79468-49-8
References:
1. Korff, J.M. and Jarabak, J. Isolation and properties of an NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase from rabbit kidney. Methods Enzymol. 86 (1982) 152-155. [PMID: 6182444]