IUBMB Enzyme Nomenclature


Accepted name: 8-oxocoformycin reductase

Reaction: coformycin + NADP+ = 8-oxocoformycin + NADPH + H+

Other name(s): 8-ketodeoxycoformycin reductase

Systematic name: coformycin:NADP+ 8-oxidoreductase

Comments: Si-specific with respect to NADPH. Also reduces 8-oxodeoxy-coformycin to the nucleoside antibiotic deoxycoformycin.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 114995-16-3


1. Hanvey, J.C., Hawkins, E.S., Baker, D.C. and Suhadolnick, R.J. 8-Ketodeoxycoformycin and 8-ketocoformycin as intermediates in the biosynthesis of 2'-deoxycoformycin and coformycin. Biochemistry 27 (1988) 5790-5795. [PMID: 3052586]

[EC created 1992]

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