IUBMB Enzyme Nomenclature


Accepted name: codeinone reductase (NADPH)

Reaction: codeine + NADP+ = codeinone + NADPH + H+

For diagram click here.

Systematic name: codeine:NADP+ oxidoreductase

Comments: Catalyses the reversible reduction of codeinone to codeine, which is a direct precursor of morphine in the opium poppy plant, Papaver somniferum.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 153302-41-1


1. Lenz, R. and Zenk, M.H. Stereoselective reduction of codeinone, the penultimate step during morphine biosynthesis in Papaver somniferum. Tetrahedron Lett. 36 (1995) 2449-2452.

2. Lenz, R. and Zenk, M.H. Purification and properties of codeinone reductase (NADPH) from Papaver somniferum cell cultures. Eur. J. Biochem. 233 (1995) 132-139. [PMID: 7588736]

[EC created 1999, modified 2001]

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