IUBMB Enzyme Nomenclature


Accepted name: sulcatone reductase

Reaction: sulcatol + NAD+ = sulcatone + NADH + H+

Glossary entries:
sulcatone: 6-methylhept-5-en-2-one
sulcatol: 6-methylhept-5-en-2-ol

Systematic name: sulcatol:NAD+ oxidoreductase

Comments: Studies on the effects of growth-stage and nutrient supply on the stereochemistry of sulcatone reduction in Clostridia pasteurianum, C. tyrobutyricum and Lactobacillus brevis suggest that there may be at least two sulcatone reductases with different stereospecificities.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 196522-54-0


1. Belan, A., Botle, J., Fauve, A., Gourcy, J.G. and Veschambre, H. Use of biological systems for the preparation of chiral molecules. 3. An application in pheromone synthesis: Preparation of sulcatol enantiomers. J. Org. Chem. 52 (1987) 256-260.

2. Tidswell, E.C., Salter, G.J., Kell, D.B. and Morris, J.G. Enantioselectivity of sulcatone reduction by some anaerobic bacteria. Enzyme Microb. Technol. 21 (1997) 143-147.

3. Tidswell, E.C., Thompson, A.N. and Morris, J.G. Selection in chemostat culture of a mutant strain of Clostridium tryobutyricum improved in its reduction of ketones. J. Appl. Microbiol. Biotechnol. 35 (1991) 317-322.

[EC created 2000, modified 2001]

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