IUBMB Enzyme Nomenclature


Accepted name: vellosimine dehydrogenase

Reaction: 10-deoxysarpagine + NADP+ = vellosimine + NADPH + H+

For diagram click here.

Systematic name: 10-deoxysarpagine:NADP+ oxidoreductase

Comments: Also acts on related alkaloids with an endo-aldehyde group as vellosimine (same stereochemistry at C-16) but only slight activity with exo-aldehydes. Detected in many cell suspension cultures of plants from the family Apocynaceae.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 86777-26-6


1. Pfitzner, A., Krausch, B. and Stöckigt, J. Characteristics of vellosimine reductase, a specific enzyme involved in the biosynthesis of the Rauwolfia alkaloid sarpagine. Tetrahedron 40 (1984) 1691-1699.

[EC created 2002]

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