IUBMB Enzyme Nomenclature


Accepted name: 3β-hydroxy-5α-steroid dehydrogenase

Reaction: 3β-hydroxy-5α-pregnane-20-one + NADP+ = 5α-pregnan-3,20-dione + NADPH + H+

For diagram click here.

Systematic name: 3β-hydroxy-5α-steroid:NADP+ 3-oxidoreductase

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 58875-02-8


1. Lindemann, P. and Luckner, M. Biosynthesis of pregnane derivatives in somatic embryos of Digitalis lanata. Phytochemistry 46 (1997) 507-513.

2. Warneck, H.M. and Seitz, H.U. 3β-Hydroxysteroid oxidoreductase in suspension cultures of Digitalis lanata EHRH. Z. Naturforsch. C: Biosci. 45 (1990) 963-972. [PMID: 2291772]

[EC created 2003]

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