IUBMB Enzyme Nomenclature


Accepted name: (S)-3-hydroxyacid-ester dehydrogenase

Reaction: ethyl (S)-3-hydroxyhexanoate + NADP+ = ethyl 3-oxohexanoate + NADPH + H+

Other name(s): 3-oxo ester (S)-reductase

Systematic name: ethyl-(S)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase

Comments: Also acts on 4-oxo- and 5-oxo-fatty acids and their esters. cf. EC (R)-3-hydroxyacid-ester dehydrogenase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 114705-03-2


1. Heidlas, J., Engel, K.-H. and Tressl, R. Purification and characterization of two oxidoreductases involved in the enantioselective reduction of 3-oxo, 4-oxo and 5-oxo esters in baker's yeast. Eur. J. Biochem. 172 (1988) 633-639. [PMID: 3280313]

[EC created 1990 as EC, transferred 2003 to EC]

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