IUBMB Enzyme Nomenclature


Accepted name: malate dehydrogenase [NAD(P)+]

Reaction: (S)-malate + NAD(P)+ = oxaloacetate + NAD(P)H + H+

Other name(s): MdH II, NAD(P)+-dependent malate dehyrogenase

Systematic name: (S)-malate:NAD(P)+ oxidoreductase

Comments: This enzyme, which was characterized from the methanogenic archaeon Methanobacterium thermoautotrophicum, catalyses only the reduction of oxaloacetate, and can use NAD+ and NADP+ with similar specific activity [1]. Different from EC [malate dehydrogenase (NAD+)], EC [malate dehydrogenase (NADP+)] and EC [malate dehydrogenase (quinone)].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Thompson, H., Tersteegen, A., Thauer, R.K. and Hedderich, R. Two malate dehydrogenases in Methanobacterium thermoautotrophicum. Arch. Microbiol. 170 (1998) 38-42. [PMID: 9639601]

[EC created 2009]

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