IUBMB Enzyme Nomenclature


Accepted name: 3-hydroxybutyrate dehydrogenase

Reaction: (R)-3-hydroxybutanoate + NAD+ = acetoacetate + NADH + H+

Other name(s): NAD-β-hydroxybutyrate dehydrogenase; hydroxybutyrate oxidoreductase; β-hydroxybutyrate dehydrogenase; D-β-hydroxybutyrate dehydrogenase; D-3-hydroxybutyrate dehydrogenase; D-(–)-3-hydroxybutyrate dehydrogenase; β-hydroxybutyric acid dehydrogenase; 3-D-hydroxybutyrate dehydrogenase; β-hydroxybutyric dehydrogenase

Systematic name: (R)-3-hydroxybutanoate:NAD+ oxidoreductase

Comments: Also oxidizes other 3-hydroxymonocarboxylic acids.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9028-38-0


1. Bergmeyer, H.-U., Gawehn, K., Klotzsch, H., Krebs, H.A. and Williamson, D.H. Purification and properties of crystalline 3-hydroxybutyrate dehydrogenase from Rhodopseudomonas spheroides. Biochem. J. 102 (1967) 423-431. [PMID: 4291491]

2. Delafield, F.P., Cooksey, K.E. and Doudoroff, M. β-Hydroxybutyric dehydrogenase and dimer hydrolase of Pseudomonas lemoignei. J. Biol. Chem. 240 (1965) 4023-4028. [PMID: 4954074]

3. Lehninger, A.L., Sudduth, H.C. and Wise, J.B. D-β-Hydroxybutyric dehydrogenase of mitochondria. J. Biol. Chem. 235 (1960) 2450-2455.

[EC created 1961]

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