Reaction: (2S)-3-sulfolactate + NAD+ = 3-sulfopyruvate + NADH + H+
Other name(s): (2S)-3-sulfolactate dehydrogenase; SlcC
Systematic name: (2S)-sulfolactate:NAD+ oxidoreductase
Comments: This enzyme, isolated from the bacterium Chromohalobacter salexigens DSM 3043, acts only on the (S)-enantiomer of 3-sulfolactate. Combined with EC 126.96.36.1998, (2R)-3-sulfolactate dehydrogenase (NADP+), it provides a racemase system that converts (2S)-3-sulfolactate to (2R)-3-sulfolactate, which is degraded further by EC 188.8.131.52, (2R)-sulfolactate sulfo-lyase. The enzyme is specific for NAD+.
Links to other databases: BRENDA, EXPASY, KEGG Metacyc, CAS registry number:
1. Denger, K. and Cook, A.M. Racemase activity effected by two dehydrogenases in sulfolactate degradation by Chromohalobacter salexigens: purification of (S)-sulfolactate dehydrogenase. Microbiology 156 (2010) 967-974. [PMID: 20007648]