IUBMB Enzyme Nomenclature


Accepted name: isoeugenol synthase

Reaction: isoeugenol + acetate + NADP+ = coniferyl acetate + NADPH + H+

For diagram of reaction click here.

Other name(s): IGS1; t-anol/isoeugenol synthase 1

Systematic name: eugenol:NADP+ oxidoreductase (coniferyl acetate reducing)

Comments: The enzyme acts in the opposite direction. In Ocimum basilicum (sweet basil), Clarkia breweri, and Petunia hybrida only isoeugenol is formed [1,2]. However in Pimpinella anisum (anise) only anol is formed in vivo, although the cloned enzyme does produce isoeugenol [3].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Koeduka, T., Fridman, E., Gang, D.R., Vassão, D.G., Jackson, B.L., Kish, C.M., Orlova, I., Spassova, S.M., Lewis, N.G., Noel, J.P., Baiga, T.J., Dudareva, N. and Pichersky, E. Eugenol and isoeugenol, characteristic aromatic constituents of spices, are biosynthesized via reduction of a coniferyl alcohol ester. Proc. Natl. Acad. Sci. USA 103 (2006) 10128-10133. [PMID: 16782809]

2. Koeduka, T., Louie, G.V., Orlova, I., Kish, C.M., Ibdah, M., Wilkerson, C.G., Bowman, M.E., Baiga, T.J., Noel, J.P., Dudareva, N. and Pichersky, E. The multiple phenylpropene synthases in both Clarkia breweri and Petunia hybrida represent two distinct protein lineages. Plant J. 54 (2008) 362-374. [PMID: 18208524]

3. Koeduka, T., Baiga, T.J., Noel, J.P. and Pichersky, E. Biosynthesis of t-anethole in anise: characterization of t-anol/isoeugenol synthase and an O-methyltransferase specific for a C7-C8 propenyl side chain. Plant Physiol. 149 (2009) 384-394. [PMID: 18987218]

[EC created 2012]

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