IUBMB Enzyme Nomenclature


Accepted name: 2-deoxy-scyllo-inosamine dehydrogenase

Reaction: 2-deoxy-scyllo-inosamine + NAD(P)+ = 3-amino-2,3-dideoxy-scyllo-inosose + NAD(P)H + H+

For diagram of reaction click here.

Glossary: 2-deoxy-scyllo-inosamine = (1R,2S,3S,4R,5S)-5-aminocyclohexane-1,2,3,4-tetrol

Other name(s): neoA (gene name); kanK (gene name, ambiguous); kanE (gene name, ambiguous)

Systematic name: 2-deoxy-scyllo-inosamine:NAD(P)+ 1-oxidoreductase

Comments: Requires zinc. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, neomycin and ribostamycin. cf. EC, 2-deoxy-scyllo-inosamine dehydrogenase (SAM-dependent).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Kudo, F., Yamamoto, Y., Yokoyama, K., Eguchi, T. and Kakinuma, K. Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773. J. Antibiot. (Tokyo) 58 (2005) 766-774. [PMID: 16506694]

2. Nepal, K.K., Oh, T.J. and Sohng, J.K. Heterologous production of paromamine in Streptomyces lividans TK24 using kanamycin biosynthetic genes from Streptomyces kanamyceticus ATCC12853. Mol. Cells 27 (2009) 601-608. [PMID: 19466609]

[EC created 2012]

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