IUBMB Enzyme Nomenclature


Accepted name: mevaldate reductase (NADPH)

Reaction: (R)-mevalonate + NADP+ = mevaldate + NADPH + H+

Other name(s): mevaldate (reduced nicotinamide adenine dinucleotide phosphate) reductase; mevaldate reductase (NADPH2)

Systematic name: (R)-mevalonate:NADP+ oxidoreductase

Comments: May be identical with EC [alcohol dehydrogenase (NADP+)].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9028-34-6


1. Coon, M.J., Kupiecki, F.P., Dekker, E.E., Schlesinger, M.J. and del Campillo, A. The enzymic synthesis of branched-chain acids. In: Wolstenholme, G.E.W. and O'Connor, M. (Eds.), CIBA Symposium on the Biosynthesis of Terpenes and Sterols, Churchill, London, 1959, p. 62-74.

2. von Wartburg, J.P. and Wermoth, B. Aldehyde reductase. In: Jakoby, W.B. (Ed.), Enzymatic Basis of Detoxication, vol. 1, Academic Press, New York, 1980, p. 249-260.

[EC created 1961]

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