IUBMB Enzyme Nomenclature


Accepted name: chanoclavine-I dehydrogenase

Reaction: chanoclavine-I + NAD+ = chanoclavine-I aldehyde + NADH + H+

For diagram of reaction click here.

Glossary: chanoclavine-I = (1E)-2-methyl-3-[(4R,5R)-4-(methylamino)-1,3,4,5-tetrahydrobenz[cd]indol-5-yl]prop-2-en-1-ol
chanoclavine-I aldehyde = (1E)-2-methyl-3-[(4R,5R)-4-(methylamino)-1,3,4,5-tetrahydrobenz[cd]indol-5-yl]prop-2-enal

Other name(s): easD (gene name); fgaDH (gene name)

Systematic name: chanoclavine-I:NAD+ oxidoreductase

Comments: The enzyme catalyses a step in the pathway of ergot alkaloid biosynthesis in certain fungi.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Wallwey, C., Matuschek, M. and Li, S.M. Ergot alkaloid biosynthesis in Aspergillus fumigatus: conversion of chanoclavine-I to chanoclavine-I aldehyde catalyzed by a short-chain alcohol dehydrogenase FgaDH. Arch. Microbiol. 192 (2010) 127-134. [PMID: 20039019]

2. Wallwey, C., Heddergott, C., Xie, X., Brakhage, A.A. and Li, S.M. Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae. Microbiology 158 (2012) 1634-1644. [PMID: 22403186]

[EC created 2012]

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