Reaction: UDP-N-acetyl-α-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-α-D-mannosaminuronate + 2 NADH + 2 H+
For diagram of reaction click here.
Other name(s): UDP-ManNAc 6-dehydrogenase; wecC (gene name)
Systematic name: UDP-N-acetyl-α-D-mannosamine:NAD+ 6-oxidoreductase
Comments: Part of the pathway for acetamido sugar biosynthesis in bacteria and archaea. The enzyme has no activity with NADP+.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:
1. Namboori, S.C. and Graham, D.E. Acetamido sugar biosynthesis in the Euryarchaea. J. Bacteriol. 190 (2008) 2987-2996. [PMID: 18263721]