IUBMB Enzyme Nomenclature


Accepted name: dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+)

Reaction: dTDP-6-deoxy-β-L-talose + NAD+ = dTDP-4-dehydro-β-L-rhamnose + NADH + H+

Glossary: dTDP-4-dehydro-β-L-rhamnose = dTDP-4-dehydro-6-deoxy-β-L-mannose
dTDP-6-deoxy-β-L-talose = dTDP-β-L-pneumose

Other name(s): tll (gene name)

Systematic name: dTDP-6-deoxy-β-L-talose:NAD+ 4-oxidoreductase

Comments: The enzyme has been characterized from the bacterium Aggregatibacter actinomycetemcomitans, in which it participates in the biosynthesis of the serotype c-specific polysaccharide antigen. Shows no activity with NADP+.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Nakano, Y., Suzuki, N., Yoshida, Y., Nezu, T., Yamashita, Y. and Koga, T. Thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans. J. Biol. Chem. 275 (2000) 6806-6812. [PMID: 10702238]

[EC created 2012]

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