IUBMB Enzyme Nomenclature


Accepted name: norsolorinic acid ketoreductase

Reaction: (1'S)-averantin + NADP+ = norsolorinic acid + NADPH + H+

For diagram of reaction click here.

Glossary: norsolorinic acid = 2-hexanoyl-1,3,6,8-tetrahydroxy-9,10-anthraquinone
(1'S)-averantin = 1,3,6,8-tetrahydroxy-[(1S)-2-hydroxyhexyl]-9,10-anthraquinone

Other name(s): aflD (gene name); nor-1 (gene name)

Systematic name: (1'S)-averantin:NADP+ oxidoreductase

Comments: Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Yabe, K., Matsuyama, Y., Ando, Y., Nakajima, H. and Hamasaki, T. Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin. Appl. Environ. Microbiol. 59 (1993) 2486-2492. [PMID: 8368836]

2. Zhou, R. and Linz, J.E. Enzymatic function of the nor-1 protein in aflatoxin biosynthesis in Aspergillus parasiticus. Appl. Environ. Microbiol. 65 (1999) 5639-5641. [PMID: 10584035]

[EC created 2013]

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