IUBMB Enzyme Nomenclature


Accepted name: aklaviketone reductase

Reaction: aklavinone + NADP+ = aklaviketone + NADPH + H+

For diagram of reaction click here.

Glossary: aklavinone = methyl (1R,2R,4S)-2-ethyl-2,4,5,7-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate
aklaviketone = methyl (1R,2R)-2-ethyl-2,5,7-trihydroxy-4,6,11-trioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate

Other name(s): dauE (gene name); aknU (gene name)

Systematic name: aklavinone:NADP+ oxidoreductase

Comments: The enzyme is involved in the synthesis of the aklavinone aglycone, a common precursor for several anthracycline antibiotics including aclacinomycins, daunorubicin and doxorubicin. The enzyme from the Gram-negative bacterium Streptomyces sp. C5 produces daunomycin.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Dickens, M.L., Ye, J. and Strohl, W.R. Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5. J. Bacteriol. 178 (1996) 3384-3388. [PMID: 8655529]

[EC created 2013]

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