IUBMB Enzyme Nomenclature


Accepted name: L-gulonate 5-dehydrogenase

Reaction: L-gulonate + NAD+ = D-fructuronate + NADH + H+

Glossary: D-fructuronate = D-arabino-hexuronate

Systematic name: L-gulonate:NAD+ 5-oxidoreductase

Comments: The enzyme, characterized from the bacterium Halomonas elongata, participates in a pathway for L-gulonate degradation.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Cooper, R.A. The pathway for L-gulonate catabolism in Escherichia coli K-12 and Salmonella typhimurium LT-2. FEBS Lett 115 (1980) 63-67. [PMID: 6993236]

2. Wichelecki, D.J., Vendiola, J.A., Jones, A.M., Al-Obaidi, N., Almo, S.C. and Gerlt, J.A. Investigating the physiological roles of low-efficiency D-mannonate and D-gluconate dehydratases in the enolase superfamily: pathways for the catabolism of L-gulonate and L-idonate. Biochemistry 53 (2014) 5692-5699. [PMID: 25145794]

[EC created 2014]

Return to EC 1.1.1 home page
Return to EC 1.1 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page