IUBMB Enzyme Nomenclature


Accepted name: glucose-6-phosphate dehydrogenase (NAD+)

Reaction: D-glucose 6-phosphate + NAD+ = 6-phospho-D-glucono-1,5-lactone + NADH + H+

Other name(s): Glc6PDH; azf (gene name); archaeal zwischenferment

Systematic name: D-glucose-6-phosphate:NAD+ 1-oxidoreductase

Comments: The enzyme catalyses a step of the pentose phosphate pathway. The enzyme from the archaeon Haloferax volcanii is specific for NAD+. cf. EC, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC, glucose-6-phosphate dehydrogenase (NADP+).

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Pickl, A. and Schonheit, P. The oxidative pentose phosphate pathway in the haloarchaeon Haloferax volcanii involves a novel type of glucose-6-phosphate dehydrogenase--The archaeal Zwischenferment. FEBS Lett. 589 (2015) 1105-1111. [PMID: 25836736]

[EC created 2015]

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