IUBMB Enzyme Nomenclature


Accepted name: tetrachlorobenzoquinone reductase

Reaction: 2,3,5,6-tetrachlorohydroquinone + NAD+ = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH + H+

Other name(s): pcpD (gene name); TCBQ reductase

Systematic name: 2,3,5,6-tetrachlorohydroquinone:NAD+ oxidoreductase

Comments: Contains FMN. The enzyme, characterized from the bacterium Sphingobium chlorophenolicum, participates in the degradation of pentachlorophenol.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Chen, L. and Yang, J. Biochemical characterization of the tetrachlorobenzoquinone reductase involved in the biodegradation of pentachlorophenol. Int J Mol Sci 9 (2008) 198-212. [PMID: 19325743]

2. Yadid, I., Rudolph, J., Hlouchova, K. and Copley, S.D. Sequestration of a highly reactive intermediate in an evolving pathway for degradation of pentachlorophenol. Proc. Natl. Acad. Sci. USA 110 (2013) E2182-E2190. [PMID: 23676275]

[EC created 2017]

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