IUBMB Enzyme Nomenclature


Accepted name: 4-phospho-D-threonate 3-dehydrogenase

Reaction: 4-phospho-D-threonate + NAD+ = glycerone phosphate + CO2 + NADH + H+ (overall reaction)
(1a) 4-phospho-D-threonate + NAD+ = 3-dehydro-4-phospho-D-threonate + NADH + H+
(1b) 3-dehydro-4-phospho-D-threonate = glycerone phosphate + CO2 (spontaneous)

For diagram of reaction click here.

Glossary: D-threonate = (2S,3R)-2,3,4-trihydroxybutanoate
glycerone phosphate = dihydroxyacetone phosphate = 3-hydroxy-2-oxopropyl phosphate

Other name(s): pdxA2 (gene name) (ambiguous)

Systematic name: 4-phospho-D-threonate:NAD+ 3-oxidoreductase

Comments: The enzyme, characterized from bacteria, is involved in a pathway for D-threonate catabolism.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Zhang, X., Carter, M.S., Vetting, M.W., San Francisco, B., Zhao, S., Al-Obaidi, N.F., Solbiati, J.O., Thiaville, J.J., de Crecy-Lagard, V., Jacobson, M.P., Almo, S.C. and Gerlt, J.A. Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars. Proc. Natl Acad. Sci. USA 113 (2016) E4161-E4169. [PMID: 27402745]

[EC created 2017]

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