IUBMB Enzyme Nomenclature


Accepted name: isopyridoxal dehydrogenase (5-pyridoxolactone-forming)

Reaction: isopyridoxal + NAD+ = 5-pyridoxolactone + NADH + H+

Glossary: isopyridoxal = 5-hydroxy-4-(hydroxymethyl)-6-methylpyridine-3-carbaldehyde
5-pyridoxolactone = 7-hydroxy-6-methylfuro[3,4-c]pyridin-3(1H)-one

Systematic name: isopyridoxal:NAD+ oxidoreductase (5-pyridoxolactone-forming)

Comments: The enzyme, characterized from the bacterium Arthrobacter sp. Cr-7, participates in the degradation of pyridoxine. The enzyme also catalyses the activity of EC, isopyridoxal dehydrogenase (5-pyridoxate-forming).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Lee, Y.C., Nelson, M.J. and Snell, E.E. Enzymes of vitamin B6 degradation. Purification and properties of isopyridoxal dehydrogenase and 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylic-acid dehydrogenase. J. Biol. Chem 261 (1986) 15106-15111. [PMID: 3533936]

[EC created 2018]

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