IUBMB Enzyme Nomenclature


Accepted name: D-apionate oxidoisomerase

Reaction: D-apionate + NAD+ = 3-oxo-D-isoapionate + NADH + H+

Glossary: 3-oxo-D-isoapionate = 2,4-dihydroxy-2-(hydroxymethyl)-3-oxobutanoate

Other name(s): apnO (gene name)

Systematic name: D-apionate:NAD+ oxidoreductase (isomerizing)

Comments: The enzyme, characterized from several bacterial species, participates in the degradation of D-apionate. The reaction involves migration of a hydroxymethyl group from position 3 to position 2 and oxidation of the 3-hydroxyl group.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Carter, M.S., Zhang, X., Huang, H., Bouvier, J.T., Francisco, B.S., Vetting, M.W., Al-Obaidi, N., Bonanno, J.B., Ghosh, A., Zallot, R.G., Andersen, H.M., Almo, S.C. and Gerlt, J.A. Functional assignment of multiple catabolic pathways for D-apiose. Nat. Chem. Biol. 14 (2018) 696-705. [PMID: 29867142]

[EC created 2019]

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