IUBMB Enzyme Nomenclature


Accepted name: (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA dehydrogenase

Reaction: (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD+ = (S)-2-benzoylsuccinyl-CoA + NADH + H+

Other name(s): bbsCD (gene name)

Systematic name: (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA:NAD+ oxidoreductase

Comments: The enzyme, purified from the bacterium Thauera aromatica, is involved in an anaerobic toluene degradation pathway. It is specific for NAD+.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. von Horsten, S., Lippert, M.L., Geisselbrecht, Y., Schuhle, K., Schall, I., Essen, L.O. and Heider, J. Inactive pseudoenzyme subunits in heterotetrameric BbsCD, a novel short-chain alcohol dehydrogenase involved in anaerobic toluene degradation. FEBS J. (2021) . [PMID: 34601806]

[EC created 2022]

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