IUBMB Enzyme Nomenclature


Accepted name: L-fucose dehydrogenase

For diagram of reaction click here

Reaction: β-L-fucopyranose + NADP+ = L-fucono-1,5-lactone + NADPH + H+

Systematic name: β-L-fucopyranose:NADP+ 1-oxidoreductase

Comments: The enzyme, characterized from the bacterium Burkholderia multivorans, participates in an L-fucose degradation pathway. The enzyme catalyses the oxidation of β-L-fucopyranose to L-fucono-1,5-lactone, which is unstable and is rapidly converted to L-fucono-1,4-lactone. The α anomer is not recognized. The enzyme can also act on β-L-galactopyranose and D-arabinose with lower activity. NADP is a better cosubstrate than NAD.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Hobbs, M.E., Vetting, M., Williams, H.J., Narindoshvili, T., Kebodeaux, D.M., Hillerich, B., Seidel, R.D., Almo, S.C. and Raushel, F.M. Discovery of an L-fucono-1,5-lactonase from cog3618 of the amidohydrolase superfamily. Biochemistry 52 (2013) 239-253. [PMID: 23214453]

[EC created 2022]

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