IUBMB Enzyme Nomenclature


Accepted name: lactate dehydrogenase (NAD+,ferredoxin)

Reaction: lactate + 2 NAD+ + 2 reduced ferredoxin [iron-sulfur] cluster = pyruvate + 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster

Other name(s): electron bifurcating LDH/Etf complex

Systematic name: lactate:NAD+,ferredoxin oxidoreductase

Comments: The enzyme, isolated from the bacterium Acetobacterium woodii, uses flavin-based electron confurcation to drive endergonic lactate oxidation with NAD+ as oxidant at the expense of simultaneous exergonic electron flow from reduced ferredoxin to NAD+.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Weghoff, M.C., Bertsch, J. and Muller, V. A novel mode of lactate metabolism in strictly anaerobic bacteria. Environ. Microbiol. 17 (2015) 670-677. [PMID: 24762045]

[EC created 2015 as EC, transferred 2022 to EC]

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