IUBMB Enzyme Nomenclature


Accepted name: 5-dehydrofumagillol 5-reductase

Reaction: fumagillol + NADP+ = 5-dehydrofumagillol + NADPH + H+

For diagram of reaction click here

Glossary: fumagillol = (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-ol

Other name(s): af490 (gene name); Fma-KR

Systematic name: fumagillol:NADP+ 5-oxidoreductase

Comments: The enzyme, characterized from the mold Aspergillus fumigatus, participates in the biosynthesis of the meroterpenoid fumagillin. It is a partial polyketide synthase (PKS) consisting of only a dehydratase (DH) and a ketoreductase (KR) domain.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Lin, H.C., Tsunematsu, Y., Dhingra, S., Xu, W., Fukutomi, M., Chooi, Y.H., Cane, D.E., Calvo, A.M., Watanabe, K. and Tang, Y. Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway. J. Am. Chem. Soc. 136 (2014) 4426-4436. [PMID: 24568283]

[EC created 2022]

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