Reaction: L-galactose + NADP+ = L-galactono-1,5-lactone + NADPH + H+
Other name(s): lgaA (gene name); Bvu0219
Systematic name: L-galactose:NADP+ 1-oxidoreductase
Comments: The enzyme, characterized from the bacterium Phocaeicola vulgatus, catalyses a step in an L-galactose utilization metabolic pathway. The product, L-galactono-1,5-lactone, can be spontaneously converted to the more stable L-galactono-1,4-lactone, but the subsequent metabolic enzyme (EC 3.1.1.126) specifically hydrolyses L-galactono-1,5-lactone. cf. EC 1.1.1.316 L-galactose 1-dehydrogenase (NAD+).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Hobbs, M.E., Williams, H.J., Hillerich, B., Almo, S.C. and Raushel, F.M. L-Galactose metabolism in Bacteroides vulgatus from the human gut microbiota. Biochemistry 53 (2014) 4661-4670. [PMID: 24963813]