IUBMB Enzyme Nomenclature


Accepted name: 3α-hydroxycholanate dehydrogenase (NAD+)

Reaction: lithocholate + NAD+ = 3-oxo-5β-cholan-24-oate + NADH + H+

For diagram of reaction click here.

Glossary: lithocholate = 3α-hydroxy-5β-cholan-24-oate

Other name(s): α-hydroxy-cholanate dehydrogenase; lithocholate:NAD+ oxidoreductase; 3α-hydroxycholanate dehydrogenase

Systematic name: lithocholate:NAD+ 3-oxidoreductase

Comments: Also acts on other 3α-hydroxysteroids with an acidic side-chain. cf. EC, 3α-hydroxycholanate dehydrogenase (NADP+).

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9028-57-3


1. Hayaishi, O., Saito, Y., Jakoby, W.B. and Stohlman, E.F. Reversible enzymatic oxidation of bile acids. Arch. Biochem. Biophys. 56 (1955) 554-555. [PMID: 14377608]

[EC created 1961, modified 1976, modified 2016]

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