IUBMB Enzyme Nomenclature


Accepted name: (S,S)-butanediol dehydrogenase

Reaction: (2S,3S)-butane-2,3-diol + NAD+ = (S)-acetoin + NADH + H+

Other name(s): L-butanediol dehydrogenase; L-BDH; L(+)-2,3-butanediol dehydrogenase (L-acetoin forming); (S)-acetoin reductase [(S,S)-butane-2,3-diol forming]

Systematic name: (S,S)-butane-2,3-diol:NAD+ oxidoreductase

Comments: This enzyme catalyses the reversible reduction of (S)-acetoin to (S,S)-butane-2,3-diol. It can also catalyse the irreversible reduction of diacetyl to (S)-acetoin.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Taylor, M.B. and Juni, E. Stereoisomeric specificities of 2,3-butanediol dehydrogenase. Biochim. Biophys. Acta 39 (1960) 448-457. [PMID: 13837186]

2. Carballo, J., Martin, R., Bernardo, A. and Gonzalez, J. Purification, characterization and some properties of diacetyl(acetoin) reductase from Enterobacter aerogenes. Eur. J. Biochem. 198 (1991) 327-332. [PMID: 2040298]

3. Takusagawa, Y., Otagiri, M., Ui, S., Ohtsuki, T., Mimura, A., Ohkuma, M. and Kudo, T. Purification and characterization of L-2,3-butanediol dehydrogenase of Brevibacterium saccharolyticum C-1012 expressed in Escherichia coli. Biosci. Biotechnol. Biochem. 65 (2001) 1876-1878. [PMID: 11577733]

[EC created 1972, modified 2010]

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