IUBMB Enzyme Nomenclature


Accepted name: methylglyoxal reductase (NADH)

Reaction: (R)-lactaldehyde + NAD+ = methylglyoxal + NADH + H+

Glossary: methylglyoxal = 2-oxopropanal

Other name(s): methylglyoxal reductase; D-lactaldehyde dehydrogenase; methylglyoxal reductase (NADH-dependent)

Systematic name: (R)-lactaldehyde:NAD+ oxidoreductase

Comments: This mammalian enzyme differs from the yeast enzyme, EC, methylglyoxal reductase (NADPH-dependent), by its cosubstrate requirement, reaction direction, and enantiomeric preference

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37250-16-1


1. Ting, S.-M., Miller, O.N. and Sellinger, O.Z. The metabolism of lactaldehyde. VII. The oxidation of D-lactaldehyde in rat liver. Biochim. Biophys. Acta 97 (1965) 407-415. [PMID: 14323585]

2. Ray, M. and Ray, S. Purification and partial characterization of a methylglyoxal reductase from goat liver. Biochim. Biophys. Acta 802 (1984) 119-127. [PMID: 6386056]

[EC created 1972, modified 2005, modified 2013]

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