IUBMB Enzyme Nomenclature


Accepted name: hydroxymethylglutaryl-CoA reductase

Reaction: (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+

For diagram click here.

Other name(s): β-hydroxy-β-methylglutaryl coenzyme A reductase (ambiguous); β-hydroxy-β-methylglutaryl CoA-reductase (ambiguous); 3-hydroxy-3-methylglutaryl coenzyme A reductase (ambiguous); hydroxymethylglutaryl coenzyme A reductase (ambiguous)

Systematic name: (R)-mevalonate:NAD+ oxidoreductase (CoA-acylating)

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37250-24-1


1. Fimognari, G.M. and Rodwell, V.W. Substrate-competitive inhibition of bacterial mevalonate:nicotinamide-adenine dinucleotide oxidoreductase (acylating CoA). Biochemistry 4 (1965) 2086-2090.

[EC created 1972, modified 2002]

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