IUBMB Enzyme Nomenclature


Accepted name: D-lactate dehydrogenase (cytochrome)

Reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c

Other name(s): lactic acid dehydrogenase; D-lactate (cytochrome) dehydrogenase; cytochrome-dependent D-(–)-lactate dehydrogenase; D-lactate-cytochrome c reductase; D-(–)-lactic cytochrome c reductase

Systematic name: (R)-lactate:ferricytochrome-c 2-oxidoreductase

Comments: A flavoprotein (FAD).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37250-79-6


1. Gregolin, C. and Singer, T.P. The lactate dehydrogenase of yeast. III. D-(–)-Lactate cytochrome c reductase, a zinc-flavoprotein from aerobic yeast. Biochim. Biophys. Acta 67 (1963) 201-218.

2. Gregolin, C., Singer, T.P., Kearney, E.B. and Boeri, E. The formation and enzymatic properties of the various lactic dehydrogenases of yeast. Ann. N.Y. Acad. Sci. 94 (1961) 780-797.

3. Nygaard, A.P. D(–)-Lactate cytochrome c reductase, a flavoprotein from yeast. J. Biol. Chem. 236 (1961) 920-925.

4. Nygaard, A.P. Lactate dehydrogenases of yeast. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 557-565.

[EC created 1961]

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