IUBMB Enzyme Nomenclature


Accepted name: D-arabinono-1,4-lactone oxidase

Reaction: D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2

For diagram click here.

Glossary: dehydro-D-arabinono-1,4-lactone = (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one

Other name(s): D-arabinono-γ-lactone oxidase; ALO

Systematic name: D-arabinono-1,4-lactone:oxygen oxidoreductase

Comments: A flavoprotein (FAD). L-Galactono-1,4-lactone, L-gulono-1,4-lactone and L-xylono-1,4-lactone can also act as substrates but D-glucono-1,5-lactone, L-arabinono-1,4-lactone, D-galactono-1,4-lactone and D-gulono-1,4-lactone cannot [1]. With L-galactono-1,4-lactone as substrate, the product is L-ascorbate [3]. The product dehydro-D-arabinono-1,4-lactone had previously been referred to erroneously as D-erythroascorbate (CAS registry number: 5776-48-7; formula: C6H8O6), although Huh et al. 1994 did refer to it as being a five-carbon compound.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 182372-12-9


1. Huh, W.K., Kim, S.T., Yang, K.S., Seok, Y.J., Hah, Y.C. and Kang, S.O. Characterisation of D-arabinono-1,4-lactone oxidase from Candida albicans ATCC 10231. Eur. J. Biochem. 225 (1994) 1073-1079. [PMID: 7957197]

[EC created 1999]

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