IUBMB Enzyme Nomenclature


Accepted name: vanillyl-alcohol oxidase

Reaction: vanillyl alcohol + O2 = vanillin + H2O2

Other name(s): 4-hydroxy-2-methoxybenzyl alcohol oxidase

Systematic name: vanillyl alcohol:oxygen oxidoreductase

Comments: Vanillyl-alcohol oxidase from Penicillium simplicissimum contains covalently bound FAD. It converts a wide range of 4-hydroxybenzyl alcohols and 4-hydroxybenzylamines into the corresponding aldehydes. The allyl group of 4-allylphenols is also converted into the -CH=CH-CH2OH group.

Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 143929-24-2


1. de Jong, E., van Berkel, W.J.H., van der Zwan, R.P. and de Bont, J.A.M. Purification and characterization of vanillyl-alcohol oxidase from Penicillium simplicissimum, a novel aromatic alcohol oxidase containing covalently bound FAD. Eur. J. Biochem. 208 (1992) 651-657. [PMID: 1396672]

2. Fraaije, M.W., Veeger, C. and van Berkel, W.J.H. Substrate specificity of flavin-dependent vanillyl-alcohol oxidase from Penicillium simplicissimum. Evidence for the production of 4-hydroxycinnamyl alcohols from 4-allylphenols. Eur. J. Biochem. 234 (1995) 271-277. [PMID: 8529652]

[EC created 1999]

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