IUBMB Enzyme Nomenclature


Accepted name: (S)-2-hydroxyglutarate dehydrogenase

Reaction: (S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol

Other name(s): L-2-hydroxyglutarate dehydrogenase; lhgO (gene name); ygaF (gene name)

Systematic name: (S)-2-hydroxyglutarate:quinone oxidoreductase

Comments: The enzyme, characterized from the bacterium Escherichia coli, contains an FAD cofactor that is not covalently attached. It is bound to the cytoplasmic membrane and is coupled to the membrane quinone pool.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Kalliri, E., Mulrooney, S.B. and Hausinger, R.P. Identification of Escherichia coli YgaF as an L-2-hydroxyglutarate oxidase. J. Bacteriol. 190 (2008) 3793-3798. [PMID: 18390652]

2. Knorr, S., Sinn, M., Galetskiy, D., Williams, R.M., Wang, C., Muller, N., Mayans, O., Schleheck, D. and Hartig, J.S. Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate. Nat. Commun. 9 (2018) 5071. [PMID: 30498244]

[EC created 2019]

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