IUBMB Enzyme Nomenclature


Accepted name: fructose 5-dehydrogenase

Reaction: D-fructose + a ubiquinone = 5-dehydro-D-fructose + a ubiquinol

Other name(s): fructose 5-dehydrogenase (acceptor); D-fructose dehydrogenase; D-fructose:(acceptor) 5-oxidoreductase

Systematic name: D-fructose:ubiquinone 5-oxidoreductase

Comments: The enzyme, characterized from the bacterium Gluconobacter japonicus, is a heterotrimer composed of an FAD-containing large subunit, a small subunit, and a heme c-containing subunit, which is responsible for anchoring the complex to the cytoplasmic membrane and for transferring the electrons to ubiquinone.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Yamada, Y., Aida, K. and Uemura, T. Enzymatic studies on the oxidation of sugar and sugar alcohol. I. Purification and properties of particle-bound fructose dehydrogenase. J. Biochem. (Tokyo) 61 (1967) 636-646. [PMID: 6059959]

2. Ameyama, M. and Adachi, O. D-Fructose dehydrogenase from Gluconobacter industrius, membrane-bound. Methods Enzymol. 89 (1982) 154-159.

3. Nakashima, K., Takei, H., Adachi, O., Shinagawa, E. and Ameyama, M. Determination of seminal fructose using D-fructose dehydrogenase. Clin. Chim. Acta 151 (1985) 307-310. [PMID: 4053391]

4. Kawai, S., Goda-Tsutsumi, M., Yakushi, T., Kano, K. and Matsushita, K. Heterologous overexpression and characterization of a flavoprotein-cytochrome c complex fructose dehydrogenase of Gluconobacter japonicus NBRC3260. Appl. Environ. Microbiol. 79 (2013) 1654-1660. [PMID: 23275508]

[EC created 1972 as EC, transferred 2021.]

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