Reaction: L-lactate + a quinone = pyruvate + a quinol
Other name(s): lldD; lctD (gene name)
Systematic name: L-lactate:quinone 2-oxidoreductase
Comments: The enzyme is associated with the membrane and transfers electrons from lactate directly to the membrane quinone pool. In the bacterium Escherichia coli the enzyme contains FMN.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Futai, M. and Kimura, H. Inducible membrane-bound L-lactate dehydrogenase from Escherichia coli. Purification and properties. J. Biol. Chem. 252 (1977) 5820-5827. [PMID: 18473]
2. Dong, J.M., Taylor, J.S., Latour, D.J., Iuchi, S. and Lin, E.C. Three overlapping lct genes involved in L-lactate utilization by Escherichia coli. J. Bacteriol. 175 (1993) 6671-6678. [PMID: 8407843]
3. Iuchi, S., Aristarkhov, A., Dong, J.M., Taylor, J.S. and Lin, E.C. Effects of nitrate respiration on expression of the Arc-controlled operons encoding succinate dehydrogenase and flavin-linked L-lactate dehydrogenase. J. Bacteriol. 176 (1994) 1695-1701. [PMID: 8132465]
4. Stansen, C., Uy, D., Delaunay, S., Eggeling, L., Goergen, J.L. and Wendisch, V.F. Characterization of a Corynebacterium glutamicum lactate utilization operon induced during temperature-triggered glutamate production. Appl. Environ. Microbiol. 71 (2005) 5920-5928. [PMID: 16204505]
5. Billig, S., Schneefeld, M., Huber, C., Grassl, G.A., Eisenreich, W. and Bange, F.C. Lactate oxidation facilitates growth of Mycobacterium tuberculosis in human macrophages. Sci. Rep. 7 (2017) 6484. [PMID: 28744015]
6. Stanley, S., Wang, X., Liu, Q., Kwon, Y.Y., Frey, A.M., Hicks, N.D., Vickers, A.J., Hui, S. and Fortune, S.M. Ongoing evolution of the Mycobacterium tuberculosis lactate dehydrogenase reveals the pleiotropic effects of bacterial adaption to host pressure. PLoS Pathog. 20 (2024) e1012050. [PMID: 38422159]