IUBMB Enzyme Nomenclature


Accepted name: glucose 1-dehydrogenase (FAD, quinone)

Reaction: D-glucose + a quinone = D-glucono-1,5-lactone + a quinol

Other name(s): glucose dehydrogenase (Aspergillus); FAD-dependent glucose dehydrogenase; D-glucose:(acceptor) 1-oxidoreductase; glucose dehydrogenase (acceptor); gdh (gene name)

Systematic name: D-glucose:quinone 1-oxidoreductase

Comments: A glycoprotein containing one mole of FAD per mole of enzyme. 2,6-Dichloroindophenol can act as acceptor. cf. EC, quinoprotein glucose dehydrogenase.

Links to other databases: BRENDA, EXPASY, KEGG Metacyc, PDB, CAS registry number:


1. Bak, T.-G. Studies on glucose dehydrogenase of Aspergillus oryzae. II. Purification and physical and chemical properties. Biochim. Biophys. Acta 139 (1967) 277-293. [PMID: 6034674]

2. Cavener, D.R. and MacIntyre, R.J. Biphasic expression and function of glucose dehydrogenase in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 80 (1983) 6286-6288. [PMID: 6413974]

3. Lovallo, N. and Cox-Foster, D.L. Alteration in FAD-glucose dehydrogenase activity and hemocyte behavior contribute to initial disruption of Manduca sexta immune response to Cotesia congregata parasitoids. J Insect Physiol 45 (1999) 1037-1048. [PMID: 12770264]

4. Inose, K., Fujikawa, M., Yamazaki, T., Kojima, K. and Sode, K. Cloning and expression of the gene encoding catalytic subunit of thermostable glucose dehydrogenase from Burkholderia cepacia in Escherichia coli. Biochim. Biophys. Acta 1645 (2003) 133-138. [PMID: 12573242]

5. Sygmund, C., Klausberger, M., Felice, A.K. and Ludwig, R. Reduction of quinones and phenoxy radicals by extracellular glucose dehydrogenase from Glomerella cingulata suggests a role in plant pathogenicity. Microbiology 157 (2011) 3203-3212. [PMID: 21903757]

6. Sygmund, C., Staudigl, P., Klausberger, M., Pinotsis, N., Djinovic-Carugo, K., Gorton, L., Haltrich, D. and Ludwig, R. Heterologous overexpression of Glomerella cingulata FAD-dependent glucose dehydrogenase in Escherichia coli and Pichia pastoris. Microb. Cell Fact. 10 (2011) 106. [PMID: 22151971]

[EC created 1972 as EC, modified 1976, transferred 2013 to EC]

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