IUBMB Enzyme Nomenclature


Accepted name: F420H2:quinone oxidoreductase

Reaction: a quinol + oxidized coenzyme F420 = a quinone + reduced coenzyme F420

Other name(s): FqoF protein

Systematic name: quinol:coenzyme-F420 oxidoreductase

Comments: An enzyme complex that contains FAD and iron-sulfur clusters. The enzyme has been described in the archaea Methanosarcina mazei and Archaeoglobus fulgidus.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Bruggemann, H., Falinski, F. and Deppenmeier, U. Structure of the F420H2:quinone oxidoreductase of Archaeoglobus fulgidus identification and overproduction of the F420H2-oxidizing subunit. Eur. J. Biochem. 267 (2000) 5810-5814. [PMID: 10971593]

2. Kunow, J., Linder, D., Stetter, K.O. and Thauer, R.K. F420H2: quinone oxidoreductase from Archaeoglobus fulgidus. Characterization of a membrane-bound multisubunit complex containing FAD and iron-sulfur clusters. Eur. J. Biochem. 223 (1994) 503-511. [PMID: 8055920]

3. Abken, H.-J. and Deppenmeier, U. Purification and properties of an F420H2 dehydrogenase from Methanosarcina mazei Gö1. FEMS Microbiol. Lett. 154 (1997) 231-237.

[EC created 2013]

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